Organ Transplantation (Demo)

A 45-year-old man undergoes a live related renal transplant and initially recovers well. Two weeks after the procedure, he develops swelling in the ipsilateral limb and over the transplant site. Despite these symptoms, his urine output is acceptable, and his serum creatinine is unchanged. What is the most likely cause?

A 45-year-old woman undergoes a renal transplant from a living related donor. She initially recovers well, but several months later, her outpatient follow-up reveals persistent hypertension and a mild decline in renal function. What is the most likely explanation for these findings?

A 50-year-old woman undergoes a deceased donor kidney transplant after a thorough pre-transplant workup. The surgery appears uneventful, and the vascular anastomoses are performed as planned. However, upon releasing the vascular clamps, the graft immediately becomes dark and mottled. Over the next hour, the transplanted kidney shows no improvement in appearance, and urine output remains absent. What is the most likely explanation for this event?

A 60-year-old woman with advanced chronic kidney disease secondary to hypertensive nephrosclerosis is being evaluated for a kidney transplant. During her workup, the transplant team assesses donor compatibility by comparing HLA antigens. Which HLA antigen is the most critical to match for successful long-term outcomes?

A 42-year-old woman, 8 months post renal transplant for focal segmental glomerulosclerosis, presents with a five-day history of feeling generally unwell. Her symptoms include jaundice, fatigue, and arthralgia. She is on a combination of tacrolimus, mycophenolate, and prednisolone. On examination, she is noted to have jaundice, widespread lymphadenopathy, and hepatomegaly. What is the most likely diagnosis?